Association Between Thiazide Diuretucs User And Risk Of Fracture At Elderly Age Pdf

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association between thiazide diuretucs user and risk of fracture at elderly age pdf

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Published: 27.01.2021

Coughlan T. Coughlan, F.

Metrics details. Stroke is a major risk factor for osteoporosis and fractures. No study has evaluated the association between diuretic use and risk of vertebral fracture in stroke patients, although a considerable proportion of stroke patients are prescribed diuretics for hypertension.

Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

Javascript is currently disabled in your browser. Several features of this site will not function whilst javascript is disabled. Received 9 July Published 14 November Volume Pages — Review by Single anonymous peer review. Editor who approved publication: Dr Sukesh Voruganti. Thiazides are widely used as antihypertensive agents with good tolerability and efficacy.

Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis

Atenolol status at 1 month for the in-trial A and in-trial plus posttrial B cohorts. Initial curves for the in-trial A and in-trial plus posttrial B cohorts and curves from year 1 onward after randomization for the in-trial C and in-trial plus posttrial D cohorts. For the initial curves A and B , in the in-trial cohort, the unadjusted hazard ratio HR was 0. Hazards ratios HRs were adjusted for age, race, sex, diabetes, baseline estimated glomerular filtration rate eGFR , prevalent cardiovascular disease CVD , body mass index, and smoking. For estrogen, analyses are for women only. During 5 additional years of posttrial follow-up, when medication use was not constrained by study protocol, fracture risk continued to be lower in users of chlorthalidone compared with lisinopril or amlodipine together or alone. Data from randomized clinical trials are lacking.


We investigated the association between thiazide use and the risk of low-energy fractures among community dwellers with Alzheimer's disease.


Ятрогенний остеопороз. Частина І

Longer use was associated with a decreased risk of low-energy fractures. The association between thiazide exposure and LEFs was assessed with conditional logistic regression. Current thiazide use was observed in Our study extends the previous knowledge of reduced fracture risk of thiazides to persons with AD, a population with significantly increased background risk of fractures. Thiazides may exert a beneficial effect on bone mineral density through their ability to decrease urinary calcium excretion [ 4 ].

Volume 9, Number 11, November , pages Background: An alleged association of chronic use of thiazide diuretics with an increased risk of bone fragility fractures has been highlighted by a relatively recent prospective cohort study. However, the concept that thiazides exert a beneficial effect on osteoporosis is still a predominant view.

Osteoporosis and hypertension are frequent and often coexisting diseases among the elderly. Recent studies suggested that both diseases may share the same etiopathology. Moreover, the treatment of hypertension can affect the bone mineral density and worsen osteoporosis. The aim of this cross-sectional study was to assess the prevalence of low bone mass and osteoporosis in postmenopausal Syrian women and investigate their relationship with hypertension and antihypertensive drugs.

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Every second in the United States, an older adult falls, making falls the No. In fact, more than 1 in 4 older people fall each year. Falls often lead to hospitalizations, hip fractures and other significant injuries, and loss of independence leading to nursing home admission. The etiology of falls in older adults is usually multifactorial and may include increasing age, female sex, chronic conditions, and medication use, among others.


PDF | Loop diuretic use has been shown to be associated with an the association between loop diuretic use and the risk of. fractures. age, methods of fracture determination, adjustment var- thiazide diuretics, other types of diuretics, to show an association between loop diuretic use among older.


Thiazide, a first-line therapy for hypertension, lowers blood pressure, increases bone mineral density, and reduces the risk of fractures. However, hyponatremia, an adverse effect of thiazide, is associated with increased risk of osteoporosis and fractures. It is currently unclear whether thiazide-associated hyponatremia TAH outweighs the protective effects of thiazide.

Затем она, наверное, вмонтирует алгоритм в защищенный чип, и через пять лет все компьютеры будут выпускаться с предустановленным чипом Цифровой крепости. Никакой коммерческий производитель и мечтать не мог о создании шифровального чипа, потому что нормальные алгоритмы такого рода со временем устаревают. Но Цифровая крепость никогда не устареет: благодаря функции меняющегося открытого текста она выдержит людскую атаку и не выдаст ключа. Новый стандарт шифрования. Отныне и навсегда.

Сьюзан вздохнула. Она чувствовала себя виноватой из-за того, что так резко говорила с коммандером. Ведь если кто и может справиться с возникшей опасностью, да еще без посторонней помощи, так это Тревор Стратмор. Он обладал сверхъестественной способностью одерживать верх над всеми, кто бросал ему вызов. Шесть месяцев назад, когда Фонд электронных границ обнародовал информацию о том, что подводная лодка АНБ прослушивает подводные телефонные кабели, Стратмор организовал утечку информации о том, что эта подводная лодка на самом деле занимается незаконным сбросом токсичных отходов.

Сьюзан отказывалась понимать.

У Мидж отвисла челюсть. - Извините, сэр… Бринкерхофф уже шел к двери, но Мидж точно прилипла к месту. - Я с вами попрощался, мисс Милкен, - холодно сказал Фонтейн.  - Я вас ни в чем не виню. - Но, сэр… - заикаясь выдавила .

Фонтейн стоял, тяжело дыша. - У нас нет причин ему не верить.  - Это прозвучало как сигнал к окончанию разговора.

Что ж, попробуйте! - Он начал нажимать кнопки мобильника.  - Ты меня недооценил, сынок. Никто позволивший себе угрожать жизни моего сотрудника не выйдет отсюда.  - Он поднес телефон к уху и рявкнул: - Коммутатор.

Сдвинув в сторону пустые пивные бутылки, Беккер устало опустил голову на руки. Мне нужно передохнуть хотя бы несколько минут, - подумал .

3 Comments

  1. AmГ­n S. 28.01.2021 at 08:40

    between diuretic use and risk of vertebral fracture in stroke patients, although a used to calculate hazard ratios (HRs) of vertebral fractures among patients according to thiazide or loop diuretic use 13%, including prevalence as high as 20% in people aged without salaries such as students, children, elderly, and.

  2. Anderhandto 28.01.2021 at 12:37

    The raw data supporting the conclusions of this manuscript will be made available by the authors, without undue reservation, to any qualified researcher.

  3. Baldo M. 06.02.2021 at 01:41

    A possible protective effect of thiazide diuretics against the risk of hip fracture was ratios (adjusted ORs) with 95% confidence intervals (95% Cl) for the association between hip fracture and reported a 30% risk reduction among users of any thiazides women 65 years of age or older residing in 3 communities.